Postdoctoral Scholar for Epigenomic Mechanisms of Memory Disruption by Early-life Seizures
Open February 14th, 2019 through June 30th, 2019
A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance.
The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. ChIP-seq, single-cell RNA-seq and subsequent interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.
(See: Patterson et al., J Neurosci, 2017;, McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neurosci, 2007).
The culturally diverse and welcoming laboratory is located on the UC Irvine campus, a rich community of Molecular and Neuroscience research within Southern California.
Candidates should have a recent PhD degree and experience in Molecular Biology, and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.
Please upload a CV, a brief statement of research accomplishments and interests, and a list of references.
Thank you, Tallie Z. Baram, MD, PhD D.D. Shepard Professor of Neurological Sciences Prof. Pediatrics, Anatomy/ Neurobiology, Neurology University of California-Irvine, CA, USA
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.